Delayed vs. Early Laparoscopic Appendectomy (DELAY) for Adult Patients with Acute Appendicitis: A Randomized Controlled Trial

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Featured Article

Patel SV, Zhang L, Mir ZM, et al. Delayed Versus Early Laparoscopic Appendectomy for Adult Patients With Acute Appendicitis: A Randomized Controlled Trial. Ann Surg. 2024;279(1):88-93. doi:10.1097/SLA.0000000000005996. 2023;389(7):612-619. doi:10.1056/NEJMoa2302344

Reviewers

Methodological Reviewer: Ashlie Nadler, MD, MSc, MPH, FRCSC, FACS, University of Toronto

Clinical Reviewer: Nori Bradley, MD, MPH, FRCSC, FACS, University of Alberta

Clinical Reviewer: Kristin DeGirolamo, MD, MSC, FRCSC, FACS, University of British Columbia

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Questions

Please read the above article and consider the following questions:

1. What is the clinical question being addressed?
2. What is the study design? Is it appropriate?
3. What are the sources of data?
4. Are the data accurate and valid?
5. What was the intervention and how was it assessed?
6. What outcomes were considered?
7. Are there other clinically important outcomes that should be considered?
8. How large and precise was the difference in the outcome?
9. Are there any factors (confounders) that might explain the differences in the results?
10. State the conclusion. Have the authors addressed the clinical question posed?
11. Does the evidence support the conclusion?