Effect of Gabapentin on Postoperative Pain

Overview

Featured Article

Han J, et al. Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial. JAMA Surg Apr 2018 ;153(4):303-311.

 

 

Expert Reviews

Methodological Reviewer: Arden Morris MD, MPH, Department of Surgery,  Stanford University 

Clinical Reviewer: Samantha Hendren MD, MPH, Department of Surgery, University of Michigan

Clinical Reviewer: Stuart McCluskey MD, PhD, FRCPC, Department of Anesthesia, University of Toronto

Supplementary Articles

Guyatt GH, Sackett DL, Cook DJ, for the Evidence Based Medicine Working Group. Users’ Guides to the Medical Literature. II. How to Use an Article about Therapy or Prevention. JAMA 1993 Dec 1; 270(21): 2598-2601

Guyatt GH, Sackett DL, Cook DJ, for the Evidence Based Medicine Working Group. Users’ Guides to the Medical Literature. II. How to Use an Article about Therapy or Prevention. JAMA 1994 Jan 5; 271(1): 59-63

Questions

Please read the above articles and be prepared to discuss the following:

  1. What is the clinical question being addressed?
  2. Was the assignment of patients to treatment randomized?
  3. Were all patients who entered the trial properly accounted for and attributed at its conclusions?
  4. Were patients, their clinicians and study personnel “blind” to treatment?
  5. Were the groups similar at the start of the trial?
  6. Aside from the experimental intervention, were the groups treated equally?
  7. How large and precise was the treatment effect?
  8. Can the results be applied to my patient care?
  9. Were all clinically important outcomes considered?
  10. Are the likely treatment benefits worth the potential harm and costs?
  11. State the conclusion. Have the authors addressed the question posed?
  12. Does the evidence support the conclusion?