Asselain B, Barlow W, Bartlett J et al. Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials. Lancet. 2018 Jan 19;1:27-39
Methodological Reviewer: Steve Latosinsky, MD, MSc, FRCSC, Department of Surgery, Western University
Clinical Reviewer: Ralph George MD, FACS, Department of Surgery, University of Toronto
Clinical Reviewer: Frances Wright, MD, MEd, FRCSC, Department of Surgery, University of Toronto
Bhandari M, Devereaux, PJ, Montaori V, et al; for the Evidence-Based Surgery Working Group. Users’ guide to the surgical literature: how to use a systematic literature review and meta-analysis. Can J Surg 2004;47(1):60-67
Please read the above articles and be prepared to discuss the following:
- What is the clinical question being addressed?
- Did the review explicitly address a sensible clinical question?
- Was the search for relevant studies detailed and exhaustive?
- Were the primary studies of high methodologic quality?
- Were assessments of studies reproducible?
- Were the results similar from study to study?
- What are the overall results of the review?
- How precise were the results?
- Were the clinically important outcomes considered?
- State the conclusion. Have the authors addressed the clinical question posed?
- Does the evidence support the conclusion?