Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma

Featured Article

Patel SP, Othus M, Chen Y, et al. Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma. N Engl J Med. 2023;388(9):813-823. doi:10.1056/NEJMoa2211437

Reviewers

Methodological Reviewer: Carolyn Nessim, MD, MSc, FRCSC, FACS, University of Ottawa

Clinical Reviewer: Andrea Covelli, MD, PhD, FRCSC, University of Toronto

Clinical Reviewer: Mai-Kim Grevais, MD, FRCSC, Université de Montréal

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Questions

Please read the above article and consider the following questions:

1. What is the clinical question being addressed?
2. What is the study design? Is it appropriate?
3. What are the sources of data?
4. Are the data accurate and valid?
5. What was the intervention and how was it assessed?
6. What outcomes were considered?
7. Are there other clinically important outcomes that should be considered?
8. How large and precise was the difference in the outcome?
9. Are there any factors (confounders) that might explain the differences in the results?
10. State the conclusion. Have the authors addressed the clinical question posed?
11. Does the evidence support the conclusion?