NSAIDS and Anastomotic Dehiscence


Featured Article

Smith SA, Roberts DJ, Lipson ME, et al. Postoperative nonsteroidal anti-inflammatory drug use and intestinal anasomotic dehiscence: a systematic review and meta-analysis. Dis Colon Rectum 2016;59:1087-1097

Expert Reviews

Methodological Reviewer: Arden Morris MD, MPH, Department of Surgery, Stanford University

Clinical Reviewer: Manoj Raval MD, MSc, FRCSC, Department of Surgery, University of British Columbia

Clinical Reviewer: Larissa Temple MD, FACS, FRCSC, Department of Surgery University of Rochester Medicine

Supplementary Article

Bhandari M, Devereaux, PJ, Montaori V, et al; for the Evidence-Based Surgery Working Group. Users’ guide to the surgical literature: how to use a systematic literature review and meta-analysis. Can J Surg 2004;47(1):60-67


Please read the provided articles and be prepared to discuss the following:

  1. What is the clinical question being addressed?
  2. Did the review explicitly address a sensible clinical question?
  3. Was the search for relevant studies detailed and exhaustive?
  4. Were the primary studies of high methodologic quality?
  5. Were assessments of studies reproducible?
  6. Were the results similar from study to study?
  7. What are the overall results of the review?
  8. How precise were the results?
  9. Were the clinically important outcomes considered?
  10. State the conclusion. Have the authors addressed the clinical question posed?
  11. Does the evidence support the conclusion?