Daniels L, Ünlü C, de Korre N, et al. Randomized controlled trial of observational versus antibiotic treatment for a first episode CT proven uncomplicated acute diverticulitis. Br J Surg 2017;104(1):52-61
Methodological Reviewer: Jason Park MD, MEd, FRCSC, FACS, Department of Surgery, University of Manitoba
Clinical Reviewer: Neil Hyman MD, FACS, Department of Surgery, University of Chicago
Clinical Reviewer: Neil Parry MD FRCSC, FACS, Department of Surgery, Western University
Mulla SM, Scott IA, Jackevicius CA, You JJ, Guyatt GH. How to Use a Noninferiority Trial Users’ Guides to the Medical Literature. 2012;308(24):2605-2611
Please read the above articles and be prepared to discuss the following:
- What is the clinical question being addressed?
- Was the assignment of patients to treatment randomized and concealed?
- Were all patients who entered the trial properly accounted for and attributed for at is conclusion?
- Were patients, their clinicians and study personnel “blind” to treatment?
- Did novel and standard treatment groups start with the same prognosis?
- Was the effect of the standard treatment preserved?
- Did the investigators analyze patients according to the treatment they received, as well as to the groups to which they were assigned?
- How large and precise was the treatment effect?
- Can the results be applied to my patient care?
- Were all patient-important outcomes considered?
- Are the likely treatment benefits worth the potential harm and costs?
- State the conclusion. Have the authors addressed the clinical question posed?
- Does the evidence support the conclusion?