Preoperative Treatment of Locally Advanced Rectal Cancer

Featured Article

Schrag D, Shi Q, Weiser MR, et al. Preoperative Treatment of Locally Advanced Rectal Cancer. N Engl J Med. 2023;389(4):322-334. doi:10.1056/NEJMoa2303269

Reviewers

Clinical Reviewer: Vallerie Gordon, MD, FRCPC, University of Manitoba

Clinical Reviewer: Michael Peacock, MD, FRCPC, University of British Columbia

Clinical Reviewer: Martin Weiser, MD, Memorial Sloan Kettering Cancer Center

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Questions

Please read the above article and consider the following questions:

1. What is the clinical question being addressed?
2. What is the study design? Is it appropriate?
3. What are the sources of data?
4. Are the data accurate and valid?
5. What was the intervention and how was it assessed?
6. What outcomes were considered?
7. Are there other clinically important outcomes that should be considered?
8. How large and precise was the difference in the outcome?
9. Are there any factors (confounders) that might explain the differences in the results?
10. State the conclusion. Have the authors addressed the clinical question posed?
11. Does the evidence support the conclusion?