Featured Article

Holcomb JB, del Junco DJ, Fox EE, et al for the PROMMTT Study Group. The prospective, observational multicenter major trauma transfusion (PROMMTT) study. Arch Surg 2012;15:1-10. doi: 10.1001/2013.jamasurg.387

Expert Reviews

Methodological Reviewer: Andy Kirkpatrick, CD, MD, MHSc, FRCSC, FACS, Departments of Surgery and Critical Care Medicine, University of Calgary and Foothills Medical Centre
Clinical Reviewer: Chad G. Ball, MD, MSc, FRCSC, FACS, Department of Surgery, University of Calgary and Foothills Medical Centre
Clinical Reviewer: K. Pavenski, MD, FRCPC, Department of Laboratory Medicine and Pathobiology, University of Toronto
Clinical Reviewer:Juan C Duchesne MD, FACS, FCCM, FCCP, Department of Surgery, Tulane University

Supplementary Article

Hansebout RR, Cornacchi SD, Haines T, et al; for the Evidence-Based Surgery Working Group. Users’ guide to the surgical literature. How to use an article about prognosis. Can J Surg 2009;52(4):328-36


  1. What is the clinical question being addressed?
  2. Was there a representative and well-defined sample of patients at a similar point in the course of the disease?
  3. Was follow-up sufficiently long and complete?
  4. Were objective and unbiased outcomes criteria used?
  5. Was there adjustment for important prognostic factor?
  6. How large is the likelihood of the outcome event(s) in a specified period of timeHow precise are the estimates of likelihood?
  7. Will the results help me in caring for my patients?
  8. Will the results lead directly to selecting or avoiding therapy?
  9. Are the results useful for reassuring or counseling patients?
  10. State the conclusion. Have the authors addressed the clinical question posed?
  11. Does the evidence support the conclusion?