Pre-Hospital Synergy: Tranexamic Acid And Blood Transfusion In Patients At Risk For Hemorrhage

Overview

 

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Featured Article

Deeb AP, Hoteit L, Li S, et al. Prehospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage. J Trauma Acute Care Surg. 2022;93(1):52-58. doi:10.1097/TA.0000000000003620

 

Reviewers

Methodological Reviewer
Kelly Vogt, MD, MSc, FRCSC, Western University
Clinical Reviewer
Nobhojit Roy, MD, PhD, MPH, FRCS, India
Clinical Reviewer
Pradeep H. Navsaria, MBChB, MMed, FCS(SA), Trauma Surgery (HPCSA), FACS, Groote Schuur Hospital and University of Cape Town

 

Questions

Please read the above article and be prepared to discuss the following:

  1. What is the clinical question being addressed? 
  2. Was the assignment of patients to treatment randomized? 
  3. Were all patients who entered the trial properly accounted for and attributed at its conclusions? 
  4. Were patients, their clinicians and study personnel “blind” to treatment? 
  5. Were the groups similar at the start of the trial? 
  6. Aside from the experimental intervention, were the groups treated equally? 
  7. How large and precise was the treatment effect? 
  8. Can the results be applied to my patient care? 
  9. Were all clinically important outcomes considered? 
  10. Are the likely treatment benefits worth the potential harm and costs? 
  11. State the conclusion. Have the authors addressed the question posed? 
  12. Does the evidence support the conclusion?