Whole Blood Resuscitation and Association with Survival in Injured Patients with an Elevated Probability of Mortality

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Featured Article

Sperry JL, Cotton BA, Luther JF, et al. Whole Blood Resuscitation and Association with Survival in Injured Patients with an Elevated Probability of Mortality. J Am Coll Surg. 2023;237(2):206-219. doi:10.1097/XCS.0000000000000708

Reviewers

Methodological Reviewer

Jordan Nantais, MD, FRCSC, University of Manitoba

Clinical Reviewer

Brodie Nolan, MD, MSc, FRCPC, University of Toronto

Clinical Reviewer

Morgan Schellenberg, MD, MPH, FRCSC, FACS, LAC+USC Medical Center

Questions

Please read the above article and consider the following questions:

1. What is the clinical question being addressed?
2. What is the study design? Is it appropriate?
3. What are the sources of data?
4. Are the data accurate and valid?
5. What was the intervention and how was it assessed?
6. What outcomes were considered?
7. Are there other clinically important outcomes that should be considered?
8. How large and precise was the difference in the outcome?
9. Are there any factors (confounders) that might explain the differences in the results?
10. State the conclusion. Have the authors addressed the clinical question posed?
11. Does the evidence support the conclusion?