Featured Article
Boffard DK, Riou B, Warren B et al, for the NovoSeven Trauma Study Group. Recombinant Factor VIIa Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients: Two Parallel Randomized, Placebo-Controlled, Double-Blind Clinical Trials. Journal of Trauma 2005; 59(1): 8-18
Expert Reviews:
Methodological Review: Karen Brasel MD, MPH, Department of Surgery, Medical College of Wisconsin
Clinical Review: John Drover MD, FRCSC, Department of Surgery, Queens University
Clinical Review: Brent Eastman MD, FACS, Department of Surgery, University of California, San Diego
Supplementary Articles
Guyatt GH, Sackett DL, Cook DJ, for the Evidence Based Medicine Working Group. Users’ Guides to the Medical Literature. II. How to Use an Article about Therapy or Prevention. JAMA 1993 Dec 1; 270(21): 2598-2601
Guyatt GH, Sackett DL, Cook DJ, for the Evidence Based Medicine Working Group. Users’ Guides to the Medical Literature. II. How to Use an Article about Therapy or Prevention. JAMA 1994 Jan 5; 271(1): 59-63
Questions
Please read the provided articles and be prepared to discuss the following:
- What is the clinical question being addressed?
- Was the assignment of patients to treatment randomized and concealed?
- Were all patients who entered the trial properly accounted for?
- Were patients, their clinicians and study personnel “blind” to treatment?
- Were the groups similar at the start of the trial?
- Aside from the experimental intervention, were the groups treated equally?
- How large and precise was the treatment effect?
- Were the study patients similar to my patients?
- Were the measured outcomes clinically relevant?
- Were all clinically important outcomes considered?
- Are my surgical skills similar to those of the study surgeons?
- State the conclusion. Have the authors addressed the clinical question?
- Does the evidence support the conclusion?