Preoperative VTE Prophylaxis

Overview

Featured Article

Selby LV, Sovel M, Sjoberg DD, et al. Preoperative chemoprophylaxis is safe in major oncology operations and effective at preventing venous thromboembolism. J Am Coll Surg. 2016;222(2):129-137

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Expert Reviews

Methodological Reviewer
Tim Pawlik MD, MPH, PhD, FACS, FRACS (Hon.) Department of Surgery, Ohio University

Clinical Reviewer
Rebecca Auer MD, MSc, FRCSC, Department of Surgery, University of Ottawa

Clinical Reviewer
Thomas Aloia MD, FACS, Department of Surgery, University of Texas, MD Anderson Cancer Center

Supplementary Articles

Rochon PA, Gurwitz JH, Sykora K et al. Reader’s guide to critical appraisal of cohort studies: 1. Role and design. BMJ 2005;330:895-897

Mamdani M, Sykora K, Li P et al. Reader’s guide to critical appraisal of cohort studies: 2. Assessing potential for confounding. BMJ 2005;330:960-2

Normand SLT, Sykora K, Li P, et al. Reader’s guide to critical appraisal of cohort studies: 3. Analytical strategies to reduce confounding. BMJ 2005;330:1021-3

Questions

Please read the above articles and be prepared to discuss the following:

  1. What is the clinical question being addressed?
  2. What is the study design? Is it appropriate?
  3. What are the sources of data?
  4. Are the data accurate and valid?
  5. What was the intervention and how was it assessed?
  6. What outcomes were considered?
  7. Are there other clinically important outcomes that should be considered?
  8. How large and precise was the difference in the outcomes?
  9. Are there any factors (confounders) that might explain the results?
  10. State the conclusion. Have the authors addressed the clinical question posed?
  11. Does the evidence support the conclusion?